Amy Schumer Wipes Instagram, Debuts New Look After Mounjaro Weight Loss

By Andrew Jackson 11/13/2025

Amy Schumer is officially hitting reset on Instagram.

The I Feel Pretty star wiped her feed of pre–weight-loss photos, keeping only a fresh carousel showing her slimmer silhouette and trademark attitude. The move aligns with her recent, open-book approach to wellness and her wry sense of humor.

On Tuesday, the 44-year-old comedian posted new shots sitting on the stairs and lounging in a swivel chair while wearing a red strapless mini dress paired with black Chanel slingback heels. "Back on my staircase bulls–t again," she captioned the post, thanking her glam team for "hooking a sister up."

She followed it with a signature dose of candor: "I actually left my house tonight. Who’s proud? I’m feeling good and happy. Deleted my old pics for no reason!" Confirming the cleanup, Schumer noted her Instagram grid has been cleared aside from the new post.

From Wegovy To Mounjaro: Schumer Shares What Worked

Earlier this year, Schumer told followers she’d dropped about 30 pounds while taking Ozempic. She later pivoted to Mounjaro after a rough stint with Wegovy, which she said caused frequent vomiting.

"Three years ago, I tried [semaglutide drug] Wegovy," Schumer recalled in an Instagram video. "I was puking, I couldn’t handle it. I don’t know if they’ve changed the formula, whatever. But anyway, I went on this telehealth meeting with [virtual care clinic] Midi Health, and it was cheap. I wanted to try it myself ’cause I wanted to recommend it to my friends who are nurses and teachers."

She continued: "Mounjaro’s been great," while acknowledging insurance hurdles: the medication typically isn’t covered unless a patient has diabetes or severe obesity. "Which most of the internet thinks I have. But I’m having a really good experience with it and I wanted to keep it real with you about that."

Medications like Ozempic, Wegovy, and Mounjaro are prescription treatments commonly used for type 2 diabetes and, for some patients, weight management. Schumer has been unusually candid about her experience, offering a real-time view of what has and hasn’t worked for her.

In the video, she described using a virtual care clinic to consult on options, saying she wanted first-hand experience before pointing friends in a direction. It’s a characteristically pragmatic and protective note that adds context to her openness.

The star also noted that cost remains a sticking point for many people seeking these medications without qualifying conditions, a reality that has fueled ongoing access debates across social media. Schumer appears less interested in parsing policy than in narrating her day-to-day — a staircase snap here, a glam shoutout there — as she finds what works for her health.

A Clean Slate With Signature Humor

Schumer’s grid reset doubles as a tone-setting moment. The star of Trainwreck and Inside Amy Schumer has long mixed frank commentary with self-deprecating punch lines, and her latest post fits the pattern: celebratory, slightly chaotic, and unfiltered.

Her caption doubled as a mini comedy routine, downplaying any deeper meaning and focusing on the dopamine hit of leaving the house — and documenting it. That tongue-in-cheek shrug keeps the conversation centered on her voice, not on speculation.

In recent weeks, she has shared swimsuit selfies, athleisure snaps, and sleek mini-dress looks, including a mirror selfie in a pink sports bra and blue sweatpants captioned, "No filter no filler no clean mirror." The throughline is confidence — and a willingness to laugh at the messiness that comes with it.

The comedian credited her glam squad for the sleek result, from the polished hair to the classic slingback heel, keeping the mood firmly in fun-night-out territory. The red dress-and-Chanel combo underscores the light, celebratory tone she’s leaning into.

While deleting posts can sometimes signal a major announcement, Schumer preempted speculation with a shrug: she did it "for no reason," a reminder that not every celebrity grid move is a coded message. Still, the reset arrived amid a run of upbeat posts showing her leaning into bold colors and pared-back styling, a visual throughline that supports her current mantra: feeling "good and happy."

Social media resets are common among celebrities who want to emphasize a new chapter or streamline how fans encounter their latest work. Schumer’s wipe reads as a playful refresh rather than a rebrand, punctuated by those "staircase" photos that have become a recurring bit on her feed.

Fans — And Celebs — Co-Sign The New Look

Support arrived in the comments section almost immediately. Fellow comedian Amy Sedaris chimed in, "You look incredible. Look at those pins!!!" Schumer replied with a wink: "My legs thank you!"

That enthusiasm mirrors the reaction to her recent appearances, where styling has leaned into bold colors and clean lines that spotlight her current silhouette. The emphasis is on fun, confidence, and candor — a combination that has kept Schumer in conversation since her breakout.

As online chatter about celebrity use of diabetes medications continues, Schumer’s straightforward updates stand out for their matter-of-fact tone and comedic self-awareness. Importantly, she isn’t positioning her posts as advice — just one comedian sharing what she’s trying in real time. "I’m feeling good and happy," she wrote, and the comments suggest fans are here for the ride.

Whether or not the grid stays minimal, Schumer’s reset underscores what has defined her career: candor, comedic timing, and a knack for steering the conversation on her own terms. For now, the message is simple — new photos, new energy, same Amy.

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